Meyd-964 !link! < HOT >

PK parameters suggest moderate oral exposure with a half‑life suitable for once‑ or twice‑daily dosing.

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| Property | Value / Description | |----------|---------------------| | | 4‑[(3‑chloro‑4‑fluorophenyl)amino]‑7‑(4‑pyridyl)‑2‑(1‑methoxy‑1H‑imidazol‑5‑yl)‑pyrrolo[2,3‑d]pyrimidine | | Molecular formula | C₂₄H₁₆ClFN₆O | | Molecular weight | 470.9 g mol⁻¹ | | SMILES | COc1nc2c(cn1)nc(Nc3ccc(Cl)c(F)c3)nc2c4cccnc4 | | CAS Registry | N/A (no publicly assigned CAS at the time of writing) | | Solubility | Sparingly soluble in aqueous buffers (≤ 10 µM at pH 7.4); soluble in DMSO, MeCN, and DMF (> 10 mM). | | Stability | Stable under ambient conditions when stored dry, protected from light; degradation observed in aqueous media at pH > 8. | | Log P (XlogP3-AA) | ≈ 3.4 (moderately lipophilic) | | pKa | Predicted basic nitrogen (imidazole) pKa ≈ 6.8 (experimental data not published). | PK parameters suggest moderate oral exposure with a