Meyd-773 ❲2026 Edition❳

Data are presented as mean ± SD. Comparisons between groups used one‑way ANOVA with Tukey’s post‑hoc test or log‑rank test for survival. Synergy was evaluated using the Chou–Talalay method (Combination Index < 1 indicates synergism). P‑values < 0.05 were considered statistically significant.

Treatment of MDA‑MB‑231 and HCC‑1806 cells with MEYD‑773 caused dose‑dependent suppression of p‑AKT (Ser473) and downstream p‑S6 (Ser235/236) with EC₅₀ values of 28 ± 5 nM and 35 ± 6 nM, respectively (Figure 2A). No significant inhibition was observed in luminal MCF‑7 cells, which harbor low basal PI3K activity, indicating target engagement is contingent on pathway activation status. MEYD-773

Secondary objectives included: