The re5dx9.exe fatal application exit is a legacy software crash, not a sign that your computer is broken. It occurs because a masterpiece from 2009 is trying to talk to 2025’s operating system and hardware using an outdated dialect.
The MT Framework engine that Resident Evil 5 uses is hypersensitive to GPU instability. If your graphics card came factory overclocked (e.g., "OC Edition") or you manually overclocked it, you need to downclock. re5dx9.exe fatal application exit