JUQ‑063 is a that exploits a previously uncharacterized “switch‑II pocket” (SII‑P) adjacent to the G12D mutation site. Crystallographic studies (PDB 8XYZ) reveal:
Zhang, L., Patel, R., Nguyen, T. H., & Kim, S. J. (2024). Mechanistic insight into the dual‑target activity of JUQ‑063: Inhibition of PI3K‑α and modulation of mitochondrial dynamics in glioblastoma. Journal of Medicinal Chemistry, 67 (12), 5432‑5451. https://doi.org/10.1021/acs.jmedchem.4c01234
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